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通过多模态数据融合探索炎症性肠病
文章来源：颈部肿物 发布时间:2021-7-5 12:58:48 点击数： 次
Exploringjointpatternsofbrainstructureandfunctionininflammatoryboweldiseasesusingmultimodaldatafusion.
通过多模态数据融合探索炎症性肠病中大脑结构和功能的联合模式。
Abstract
Agrowingnumberofneuroimagingstudiessuggestdistinctneuralchangesininflammatoryboweldiseases(IBDs).WhethersuchchangesmayshowsimilarspatialpatternsacrossdistinctneuralfeatureswithinandbetweenspecificIBDisunclear.Toaddressthisquestion,weusedmultivariatemultimodaldatafusionanalysistoinvestigatestructure/functionmodulationinremittedpatientswithCrohnsdisease(CD)andulcerativecolitis(UC).PatientswithIBD(n=46;n=31withCD,n=15withUC)instableremissionand17healthycontrols(HC)underwentstructuralmagneticresonanceimaging(sMRI)andresting-statefunctionalmagneticresonanceimaging(rs-fMRI)aswellascognitivetesting.Anxiety,depression,andfatiguewereassessedusingself-ratingquestionnaires.sMRIdatawereanalyzedviavoxel-basedmorphometry(VBM)andrs-fMRIdataviaamplitudeoflow-frequencyfluctuations(ALFFs)andregionalhomogeneity(ReHo).Detectionofcross-informationbetweenVBM,ALFF,andReHowasconductedbymeansofajointindependent
